Mitochondria as the target of the pro-apoptotic protein Bax
نویسندگان
چکیده
منابع مشابه
Mitochondria as the target of the pro-apoptotic protein Bax.
During apoptosis, engagement of the mitochondrial pathway involves the permeabilization of the outer mitochondrial membrane (OMM), which leads to the release of cytochrome c and other apoptogenic proteins such as Smac/DIABLO, AIF, EndoG, Omi/HtraA2 and DDP/TIMM8a. OMM permeabilization depends on activation, translocation and oligomerization of multidomain Bcl-2 family proteins such as Bax or Ba...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2006
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2006.05.032